This technical brief, co-presented by Enola Technologies and Dassault Systèmes, explores the capabilities of the Teamwork Cloud REST API and its role in enabling efficient Model-Based Systems Engineering (MBSE) workflows. Covering foundational concepts and advanced applications, it demonstrates how REST API endpoints can be used for administrative automation, project data extraction, and systems interoperability. Highlights include examples for user management, data analysis integration with tools like Power BI, and advanced activity mapping from Cameo. The presentation concludes with a look at future directions, including Webhooks, SysML v2 alignment, and evolving API standards.